A New Genetic Mutant of Apolipoprotein E—Apo E-5

Detection of a new canine parvovirus mutant in Iran

BACKGROUND: Canine Parvovirus (CPV) is one of the major causes of fatal gastroenteritis in young dogs. After emergence of CPV-2, two new variants were reported and named CPV-2a and CPV-2b. In 2001 the newest variant was reported and named CPV-2c. The difference between CPV strains is related to amino acid changes in viral capsid protein (VP2). OBJECTIVES: The aim of the present study was geneti...

Lipoprotein glomerulopathy: a new role for apolipoprotein E?

Nearly 140 years have passed since Virchow first associated lipid abnormalities with renal disease, but despite a barge body of clinical and laboratory investigation, the precise robe of lipids in the development of kidney diseases has remained elusive. Although it has been demonstrated that abnormalities in lipid metabolism may promote glomerular injury, altered glomerular function can also ch...

Genetic association of apolipoprotein E with age-related macular degeneration.

Age-related macular degeneration (AMD) is the most common geriatric eye disorder leading to blindness and is characterized by degeneration of the neuroepithelium in the macular area of the eye. Apolipoprotein E (apoE), the major apolipoprotein of the CNS and an important regulator of cholesterol and lipid transport, appears to be associated with neurodegeneration. The apoE gene (APOE) polymorph...

Genetic Variability of Apolipoprotein E in Different Populations from Venezuela

The genetic variation at the Apolipoprotein E locus (APOE) is an important determinant of plasma lipids and has been implicated in various human pathological conditions. The objective of the present study was to estimate the distribution of APOE alleles in five Venezuelan communities: two Amerindian tribes (Bari and Yucpa), one Negroid population from Curiepe, one Caucasoid population from Colo...

Frequency of Apolipoprotein E Alleles in Iranian Populations